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Reduced α4 subunit expression in α4(+−) and α4(+−)/β2(+−) nicotinic acetylcholine receptors alters α4β2 subtype up‐regulation following chronic nicotine treatment
BACKGROUND AND PURPOSE: Genomic analysis has shown many variants in both CHRNA4 and CHRNB2, genes which encode the α4 and β2 subunits of nicotinic ACh receptors (nAChR) respectively. Some variants influence receptor expression, raising the possibility that CHRNA4 variants may affect response to toba...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980142/ https://ncbi.nlm.nih.gov/pubmed/28585241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13896 |
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