Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4

MIF is a chemokine-like cytokine that plays a role in the pathogenesis of inflammatory and cardiovascular disorders. It binds to the chemokine-receptors CXCR2/CXCR4 to trigger atherogenic leukocyte migration albeit lacking canonical chemokine structures. We recently characterized an N-like-loop and...

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Published in:Sci Rep
Main Authors: Lacy, Michael, Kontos, Christos, Brandhofer, Markus, Hille, Kathleen, Gröning, Sabine, Sinitski, Dzmitry, Bourilhon, Priscila, Rosenberg, Eric, Krammer, Christine, Thavayogarajah, Tharshika, Pantouris, Georgios, Bakou, Maria, Weber, Christian, Lolis, Elias, Bernhagen, Jürgen, Kapurniotu, Aphrodite
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979958/
https://ncbi.nlm.nih.gov/pubmed/29581527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23554-5
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