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Stepwise occlusion of the carotid arteries of the rat: MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes

Bilateral common carotid artery occlusion (BCCAo) in the rat is a widely used animal model of vascular dementia and a valuable tool for preclinical pharmacological drug testing, although the varying degrees of acute focal ischemic lesions it induces could interfere with its translational value. Rece...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nyitrai, Gabriella, Spisák, Tamás, Spisák, Zsófia, Gajári, Dávid, Diószegi, Pálma, Kincses, Tamás Zsigmond, Czurkó, András
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979036/
https://ncbi.nlm.nih.gov/pubmed/29851990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198265
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