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Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer

The efficacy and safety of an immunoconjugate (icon) molecule, composed of a mutated mouse factor VII (mfVII) targeting domain and the Fc effector domain of an IgG1 Ig (mfVII/Fc icon), was tested with a severe combined immunodeficient (SCID) mouse model of human prostatic cancer and an immunocompete...

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Bibliografiske detaljer
Main Authors: Hu, Zhiwei, Garen, Alan
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC59788/
https://ncbi.nlm.nih.gov/pubmed/11593034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201420298
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