The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay

Histone deacetylase 3 (HDAC3) is a potential target for the treatment of human diseases such as cancers, diabetes, chronic inflammation and neurodegenerative diseases. Previously, we proposed a virtual screening (VS) pipeline named “Hypo1_FRED_SAHA-3” for the discovery of HDAC3 inhibitors (HDAC3Is)...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Xia, Jie, Hu, Huabin, Xue, Wenjie, Wang, Xiang Simon, Wu, Song
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5978667/
https://ncbi.nlm.nih.gov/pubmed/29464997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1437156
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