Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro

Glioblastoma is the most aggressive type of glioma. The Wingless (Wnt) signaling pathway has been shown to promote stem cell properties and resistance to radio- and chemotherapy in glioblastoma. Here, we demonstrate that pharmacological Wnt pathway inhibition using the porcupine inhibitor LGK974 act...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Suwala, Abigail Kora, Koch, Katharina, Rios, Dayana Herrera, Aretz, Philippe, Uhlmann, Constanze, Ogorek, Isabella, Felsberg, Jörg, Reifenberger, Guido, Köhrer, Karl, Deenen, René, Steiger, Hans-Jakob, Kahlert, Ulf D., Maciaczyk, Jaroslaw
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5978259/
https://ncbi.nlm.nih.gov/pubmed/29854309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25210
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