A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics

Rexinoids are powerful ligands that bind to retinoid-X-receptors (RXRs) and show great promise as therapeutics for a wide range of diseases, including cancer. However, only one rexinoid, bexarotene (Targretin TM) has been successfully transitioned from the bench to the clinic and used to treat cutan...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Steroids
Autori principali: Hanish, Bentley J., Hackney Price, Jennifer F., Kaneko, Ichiro, Ma, Ning, van der Vaart, Arjan, Wagner, Carl E., Jurutka, Peter W., Marshall, Pamela A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977990/
https://ncbi.nlm.nih.gov/pubmed/29704526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2018.04.009
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi