A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics

Rexinoids are powerful ligands that bind to retinoid-X-receptors (RXRs) and show great promise as therapeutics for a wide range of diseases, including cancer. However, only one rexinoid, bexarotene (Targretin TM) has been successfully transitioned from the bench to the clinic and used to treat cutan...

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Bibliografische gegevens
Gepubliceerd in:Steroids
Hoofdauteurs: Hanish, Bentley J., Hackney Price, Jennifer F., Kaneko, Ichiro, Ma, Ning, van der Vaart, Arjan, Wagner, Carl E., Jurutka, Peter W., Marshall, Pamela A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977990/
https://ncbi.nlm.nih.gov/pubmed/29704526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2018.04.009
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