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Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches

Polio viral proteinase 2A performs several essential functions in genome replication. Its inhibition prevents viral replication, thus making it an excellent substrate for drug development. In this study, the three-dimensional structure of 2A protease was determined and optimized by homology modellin...

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Publicat a:Genes (Basel)
Autors principals: Younus, Amna, Munawar, Saba, Bhatti, Muhammad Faraz, Ikram, Aqsa, Awan, Faryal Mehwish, Jabeen, Ishrat, Virk, Nasar, Janjua, Hussnain Ahmed, Arshad, Muhammad
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5977168/
https://ncbi.nlm.nih.gov/pubmed/29701718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9050228
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