Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Mammalian cells can respond to damage or stress by entering a state of arrested growth and altered function termed cellular senescence. Several lines of evidence suggest that the senescence response suppresses tumorigenesis. Cellular senescence is also thought to contribute to aging, but the mechani...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Krtolica, Ana, Parrinello, Simona, Lockett, Stephen, Desprez, Pierre-Yves, Campisi, Judith
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC59769/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11593017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211053698
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