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The Yin and Yang of SagS: Distinct Residues in the HmsP Domain of SagS Independently Regulate Biofilm Formation and Biofilm Drug Tolerance

The formation of inherently drug-tolerant biofilms by the opportunistic pathogen Pseudomonas aeruginosa requires the sensor-regulator hybrid SagS, with ΔsagS biofilms being unstructured and exhibiting increased antimicrobial susceptibility. Recent findings indicated SagS to function as a switch to c...

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Bibliografiske detaljer
Udgivet i:mSphere
Main Authors: Dingemans, Jozef, Poudyal, Bandita, Sondermann, Holger, Sauer, Karin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976881/
https://ncbi.nlm.nih.gov/pubmed/29848761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00192-18
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