Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions

Glioblastoma multiforme (GBM), the most common form of primary malignant brain cancer in adults, is a devastating disease for which effective treatment has remained elusive for over 75 years. One reason for the minimal progress during this time is the lack of accurate preclinical models to represent...

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Foilsithe in:Sci Rep
Main Authors: Gilbert, Ashley N., Anderson, Joshua C., Duarte, Christine W., Shevin, Rachael S., Langford, Catherine P., Singh, Raj, Gillespie, G. Yancey, Willey, Christopher D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976646/
https://ncbi.nlm.nih.gov/pubmed/29849102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26840-4
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