Hetero-Multivalency of Pseudomonas aeruginosa Lectin LecA Binding to Model Membranes

A single glycan-lectin interaction is often weak and semi-specific. Multiple binding domains in a single lectin can bind with multiple glycan molecules simultaneously, making it difficult for the classic “lock-and-key” model to explain these interactions. We demonstrated that hetero-multivalency, a...

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Publicat a:Sci Rep
Autors principals: Worstell, Nolan C., Singla, Akshi, Saenkham, Panatda, Galbadage, Thushara, Sule, Preeti, Lee, Dongheon, Mohr, Alec, Kwon, Joseph Sang-Il, Cirillo, Jeffrey D., Wu, Hung-Jen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976636/
https://ncbi.nlm.nih.gov/pubmed/29849092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26643-7
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