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Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate proteoglycans (CSPGs) within the glial scar inhibit axonal regeneration, an action mediated by the sulfated glycosaminoglycan (...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Pearson, Craig S, Mencio, Caitlin P, Barber, Amanda C, Martin, Keith R, Geller, Herbert M
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976435/
https://ncbi.nlm.nih.gov/pubmed/29762123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37139
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