Discovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells

We report for the first time the mechanism of action of the natural product thalicthuberine (TH) in prostate and cervical cancer cells. TH induced a strong accumulation of LNCaP cells in mitosis, severe mitotic spindle defects, and asymmetric cell divisions, ultimately leading to mitotic catastrophe...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Levrier, Claire, Rockstroh, Anja, Gabrielli, Brian, Kavallaris, Maria, Lehman, Melanie, Davis, Rohan A., Sadowski, Martin C., Nelson, Colleen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976206/
https://ncbi.nlm.nih.gov/pubmed/28749250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1356512
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