Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design

Recent clinical advances with chimeric antigen receptor (CAR) T cells have led to the accelerated clinical approval of CD19-CARs to treat acute lymphoblastic leukemia. The CAR T cell therapy is nevertheless associated with toxicities, especially if the CARs are not entirely tumor-specific. Therefore...

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Udgivet i:PLoS One
Main Authors: Drent, Esther, Poels, Renée, Mulders, Manon J., van de Donk, Niels W. C. J., Themeli, Maria, Lokhorst, Henk M., Mutis, Tuna
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976165/
https://ncbi.nlm.nih.gov/pubmed/29847570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197349
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