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Structure of Human Synaptotagmin 1 C2AB in the absence of Ca(+2) Reveals a Novel Domain Association

Release of neurotransmitter from synaptic vesicles requires the Ca(+2)/phospholipid binding protein, synaptotagmin 1. There is considerable evidence that cooperation between the tandem C2 domains of synaptotagmin is a requirement of regulated exocytosis; however, high-resolution structural evidence...

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Publicat a:Biochemistry
Autors principals: Fuson, Kerry L., Montes, Miguel, Robert, J. Justin, Sutton, R. Bryan
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975968/
https://ncbi.nlm.nih.gov/pubmed/17956130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701651k
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