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Linking coupled motions and entropic effects to the catalytic activity of 2-deoxyribose-5-phosphate aldolase (DERA)

DERA, 2-deoxyribose-5-phosphate aldolase, catalyzes the retro-aldol cleavage of 2-deoxy-ribose-5-phosphate (dR5P) into glyceraldehyde-3-phosphate (G3P) and acetaldehyde in a branch of the pentose phosphate pathway. In addition to the physiological reaction, DERA also catalyzes the reverse addition r...

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Détails bibliographiques
Publié dans:Chem Sci
Auteurs principaux: Ma, Huan, Szeler, Klaudia, Kamerlin, Shina C. L., Widersten, Mikael
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975929/
https://ncbi.nlm.nih.gov/pubmed/29910900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03666f
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