A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis

The caspases are a family of cysteine proteases that are key regulators of apoptosis and their activity may thus serve as a good marker to monitor cell death. We have developed a quenched fluorescent activity-based probe (qABP) that is selective for caspase-3 activity and emits a fluorescent signal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Sci
Prif Awduron: Shaulov-Rotem, Yulia, Merquiol, Emmanuelle, Weiss-Sadan, Tommy, Moshel, Ofra, Salpeter, Seth, Shabat, Doron, Kaschani, Farnusch, Kaiser, Markus, Blum, Galia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2016
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975724/
https://ncbi.nlm.nih.gov/pubmed/29910890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03207e
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