Lipid homeostasis is maintained by dual targeting of the mitochondrial PE biosynthesis enzyme to the ER

Spatial organization of phospholipid synthesis in eukaryotes is critical for cellular homeostasis. The synthesis of phosphatidylcholine, the most abundant cellular phospholipid, occurs redundantly via the ER-localized Kennedy pathway and a pathway that traverses the ER and mitochondria via membrane...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Friedman, Jonathan R., Kannan, Muthukumar, Toulmay, Alexandre, Jan, Calvin H., Weissman, Jonathan S., Prinz, William A., Nunnari, Jodi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975648/
https://ncbi.nlm.nih.gov/pubmed/29290583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.11.023
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