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Lipid homeostasis is maintained by dual targeting of the mitochondrial PE biosynthesis enzyme to the ER

Spatial organization of phospholipid synthesis in eukaryotes is critical for cellular homeostasis. The synthesis of phosphatidylcholine, the most abundant cellular phospholipid, occurs redundantly via the ER-localized Kennedy pathway and a pathway that traverses the ER and mitochondria via membrane...

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Dettagli Bibliografici
Pubblicato in:Dev Cell
Autori principali: Friedman, Jonathan R., Kannan, Muthukumar, Toulmay, Alexandre, Jan, Calvin H., Weissman, Jonathan S., Prinz, William A., Nunnari, Jodi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975648/
https://ncbi.nlm.nih.gov/pubmed/29290583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.11.023
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