Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors

Kinase gene fusions are important drivers of oncogenic transformation and can be inhibited with targeted therapies. Clinical grade diagnostics using RNA sequencing to detect gene rearrangements in solid tumors are limited, and the few that are available require prior knowledge of fusion break points...

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Publicat a:J Mol Diagn
Autors principals: Reeser, Julie W., Martin, Dorrelyn, Miya, Jharna, Kautto, Esko A., Lyon, Ezra, Zhu, Eliot, Wing, Michele R., Smith, Amy, Reeder, Matthew, Samorodnitsky, Eric, Parks, Hannah, Naik, Karan R., Gozgit, Joseph, Nowacki, Nicholas, Davies, Kurtis D., Varella-Garcia, Marileila, Yu, Lianbo, Freud, Aharon G., Coleman, Joshua, Aisner, Dara L., Roychowdhury, Sameek
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975628/
https://ncbi.nlm.nih.gov/pubmed/28802831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2017.05.006
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