Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

The activation of microglial NADPH oxidase (NOX2) induced by α-synuclein has been implicated in Parkinson's disease (PD) and other synucleinopathies. However, how α-synuclein activates NOX2 remains unclear. Previous study revealed that both toll-like receptor 2 (TLR2) and integrin play importan...

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Enregistré dans:
Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Hou, Liyan, Bao, Xiuqi, Zang, Caixia, Yang, Hanyu, Sun, Fuqiang, Che, Yuning, Wu, Xuefei, Li, Shao, Zhang, Dan, Wang, Qingshan
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975218/
https://ncbi.nlm.nih.gov/pubmed/29154191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.11.010
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