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Effect of sample size re-estimation in adaptive clinical trials for Alzheimer's disease and mild cognitive impairment
INTRODUCTION: The sample size re-estimation (SSR) adaptive design allows interim analyses and resultant modifications of the ongoing trial to preserve or increase power. We investigated the applicability of SSR in Alzheimer's disease (AD) trials using a meta-database of clinical studies. METHOD...
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| Publicado no: | Alzheimers Dement (N Y) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5975045/ https://ncbi.nlm.nih.gov/pubmed/29854926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2015.03.002 |
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