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Effect of sample size re-estimation in adaptive clinical trials for Alzheimer's disease and mild cognitive impairment

INTRODUCTION: The sample size re-estimation (SSR) adaptive design allows interim analyses and resultant modifications of the ongoing trial to preserve or increase power. We investigated the applicability of SSR in Alzheimer's disease (AD) trials using a meta-database of clinical studies. METHOD...

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Dettagli Bibliografici
Pubblicato in:Alzheimers Dement (N Y)
Autori principali: Wang, Guoqiao, Kennedy, Richard E., Cutter, Gary R., Schneider, Lon S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975045/
https://ncbi.nlm.nih.gov/pubmed/29854926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2015.03.002
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