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Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin

The aim of this pharmacokinetic evaluation was to show the effect of the extra methyl group in simvastatin on esterase hydrolysis between lovastatin and simvastatin in male and female volunteers. This study was based on the plasma concentration-time curves and the pharmacokinetics of lovastatin and...

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Bibliografiske detaljer
Udgivet i:ScientificWorldJournal
Main Authors: Vree, Tom B., Dammers, Erik, Ulc, Ivan, Horkovics-Kovats, Stefan, Ryska, Miroslav, Merkx, IJsbrand
Format: Artigo
Sprog:Inglês
Udgivet: TheScientificWorldJOURNAL 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974895/
https://ncbi.nlm.nih.gov/pubmed/14755114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1100/tsw.2003.121
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