Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers

BACKGROUND: Kisspeptin is a critical hypothalamic regulator of reproductive function. Chronic kisspeptin administration causes profound tachyphylaxis in male monkeys and in women with functional hypothalamic amenorrhea. The pharmacological effects of chronic kisspeptin exposure in healthy women with...

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Autori principali: Jayasena, C. N., Comninos, A. N., Nijher, G. M. K., Abbara, A., De Silva, A., Veldhuis, J. D., Ratnasabapathy, R., Izzi-Engbeaya, C., Lim, A., Patel, D. A., Ghatei, M. A., Bloom, S. R., Dhillo, W. S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2013
Soggetti:
Endocrine Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111853/
https://ncbi.nlm.nih.gov/pubmed/24030945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2013-1069
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