Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis

The inhibition of apoptosis, disruption of cellular microtubule dynamics, and over-activation of the epithelial mesenchymal transition (EMT), are involved in the progression, metastasis, and resistance of colorectal cancer (CRC) to chemotherapy. Therefore, the design of a molecule that can target th...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Amawi, Haneen, Hussein, Noor A., Ashby, Charles R., Alnafisah, Rawan, Sanglard, Leticia M., Manivannan, Elangovan, Karthikeyan, Chandrabose, Trivedi, Piyush, Eisenmann, Kathryn M., Robey, Robert W., Tiwari, Amit K.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974752/
https://ncbi.nlm.nih.gov/pubmed/29875662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00520
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