Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy

Multidrug-resistant (MDR) tuberculosis, defined as tuberculosis resistant to the two first-line drugs isoniazid and rifampin, poses a serious problem for global tuberculosis control strategies. Lack of a safe and convenient model organism hampers progress in combating the spread of MDR strains of My...

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Publicado en:mBio
Autores principales: Vilchèze, Catherine, Copeland, Jacqueline, Keiser, Tracy L., Weisbrod, Torin, Washington, Jacqueline, Jain, Paras, Malek, Adel, Weinrick, Brian, Jacobs, William R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974470/
https://ncbi.nlm.nih.gov/pubmed/29844114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00938-18
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