Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a

Disruption of the blood-brain barrier (BBB) by cancer cells is linked to metastatic tumor initiation and progression; however, the pathways that drive these events remain poorly understood. Here, we have developed novel patient-derived xenograft (PDX) models of brain metastases that recapitulate pat...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Tiwary, Shweta, Morales, John E., Kwiatkowski, Sam C., Lang, Frederick F., Rao, Ganesh, McCarty, Joseph H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974340/
https://ncbi.nlm.nih.gov/pubmed/29844613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26636-6
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