Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates

α-synuclein plays a key role in the pathogenesis of Parkinson’s disease (PD); its deposits are found as amyloid fibrils in Lewy bodies and Lewy neurites, the histopathological hallmarks of PD. Amyloid fibrillation is a progressive polymerization path starting from peptide/protein misfolding and proc...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Palazzi, Luana, Bruzzone, Elena, Bisello, Giovanni, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Polverino de Laureto, Patrizia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974307/
https://ncbi.nlm.nih.gov/pubmed/29844450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26645-5
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