Induction of anergic or regulatory tumor-specific CD4(+) T cells in the tumor-draining lymph node

CD4(+) T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human cancers are not secreted. The fate of Ag-specific CD4(+) T cells recognizing a cytoplasmic Ag in mice bearing autochthonous tumors is still...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Alonso, Ruby, Flament, Héloïse, Lemoine, Sébastien, Sedlik, Christine, Bottasso, Emanuel, Péguillet, Isabel, Prémel, Virginie, Denizeau, Jordan, Salou, Marion, Darbois, Aurélie, Núñez, Nicolás Gonzalo, Salomon, Benoit, Gross, David, Piaggio, Eliane, Lantz, Olivier
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974295/
https://ncbi.nlm.nih.gov/pubmed/29844317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04524-x
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