Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α

The binding of tumor necrosis factor alpha (TNF-α) to the type-1 TNF receptor (TNFRc1) plays an important role in inflammation. Despite the clinical success of biologics (antibodies, soluble receptors) for treating TNF-based autoimmune conditions, no potent small molecule antagonists have been devel...

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Main Authors: Carter, Percy H., Scherle, Peggy A., Muckelbauer, Jodi A., Voss, Matthew E., Liu, Rui-Qin, Thompson, Lorin A., Tebben, Andrew J., Solomon, Kimberly A., Lo, Yvonne C., Li, Zhong, Strzemienski, Paul, Yang, Gengjie, Falahatpisheh, Nikoo, Xu, Meizhong, Wu, Zhongren, Farrow, Neil A., Ramnarayan, Kal, Wang, Jing, Rideout, Darryl, Yalamoori, Venkatachalapathi, Domaille, Peter, Underwood, Dennis J., Trzaskos, James M., Friedman, Steven M., Newton, Robert C., Decicco, Carl P.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC59736/
https://ncbi.nlm.nih.gov/pubmed/11592999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211178398
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https://ncbi.nlm.nih.gov/pmc/articles/PMC59736/
https://ncbi.nlm.nih.gov/pubmed/11592999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211178398