Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE(-/-) mice

BACKGROUND: The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (CB1) and anti-inflammatory CB2. While the role of both receptors in atherogenesis has been studied extensively, the significance of 2-...

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Publicado en:PLoS One
Autores principales: Jehle, Julian, Schöne, Benedikt, Bagheri, Sayeh, Avraamidou, Elina, Danisch, Melina, Frank, Imke, Pfeifer, Philipp, Bindila, Laura, Lutz, Beat, Lütjohann, Dieter, Zimmer, Andreas, Nickenig, Georg
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973571/
https://ncbi.nlm.nih.gov/pubmed/29813086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197751
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