The Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension is Regulated through a MiR-124/PTBP1/PKM Axis

BACKGROUND: An emerging “metabolic theory” of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We and others have previously demonstrated the existence of hyper-proliferative, apoptosis-resistant, pro-inflammatory adv...

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Published in:Circulation
Main Authors: Zhang, Hui, Wang, Daren, Li, Min, Plecitá-Hlavatá, Lydie, D'Alessandro, Angelo, Tauber, Jan, Riddle, Suzette, Kumar, Sushil, Flockton, Amanda, McKeon, B. Alexandre, Frid, Maria G., Reisz, Julie A., Caruso, Paola, El Kasmi, Karim C., Ježek, Petr, Morrell, Nicholas W., Hu, Cheng-jun, Stenmark, Kurt R.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973494/
https://ncbi.nlm.nih.gov/pubmed/28972001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.028069
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