Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Co-Repressor C-terminal Binding Protein-1

BACKGROUND: Changes in metabolism have been suggested to contribute to the aberrant phenotype of vascular wall cells including fibroblasts in pulmonary hypertension (PH). Herein, we test the hypothesis that metabolic reprogramming to aerobic glycolysis is a critical adaptation of fibroblasts in the...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Li, Min, Riddle, Suzette, Zhang, Hui, D’Alessandro, Angelo, Flockton, Amanda, Serkova, Natalie J., Hansen, Kirk C., Moldvan, Radu, McKeon, B. Alexandre, Frid, Maria, Kumar, Sushil, Li, Hong, Liu, Hongbing, Cánovas, Angela, Medrano, Juan F., Thomas, Milton G., Iloska, Dijana, Plecita-Hlavata, Lydie, Ježek, Petr, Pullamsetti, Soni, Fini, Mehdi A., El Kasmi, Karim C., Zhang, Qinghong, Stenmark, Kurt R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069179/
https://ncbi.nlm.nih.gov/pubmed/27562971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.023171
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