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Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways

Understanding the functional properties of cells of different origins is a long-standing challenge of personalized medicine. Especially in cancer, the high heterogeneity observed in patients slows down the development of effective cures. The molecular differences between cell types or between health...

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Veröffentlicht in:Front Physiol
Hauptverfasser: De Landtsheer, Sébastien, Lucarelli, Philippe, Sauter, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972629/
https://ncbi.nlm.nih.gov/pubmed/29872402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00550
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