TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy

Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. These ligands can induce hypertrophic growth of neonatal rat cardiomyocytes (NRCMs) mainly through Ca(2+)-dependent calcineurin/nuclear factor of activat...

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Vydáno v:Front Pharmacol
Hlavní autoři: Sunggip, Caroline, Shimoda, Kakeru, Oda, Sayaka, Tanaka, Tomohiro, Nishiyama, Kazuhiro, Mangmool, Supachoke, Nishimura, Akiyuki, Numaga-Tomita, Takuro, Nishida, Motohiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972289/
https://ncbi.nlm.nih.gov/pubmed/29872396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00523
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