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Tailoring supersaturation from amorphous solid dispersions
The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected. Howe...
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| Pubblicato in: | J Control Release |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5972073/ https://ncbi.nlm.nih.gov/pubmed/29654798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.04.014 |
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