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Dual TGF-β and PD-1 blockade: a strategy for immune-excluded tumors?

Tumors that elude infiltration by CD8(+) T lymphocytes are particularly resistant to multiple forms of treatment, including immune checkpoint blockade. Stromal TGF-β appears to play a key role in this process, potentially constituting a target for novel combinatorial regimens tackling immune-exclude...

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Bibliografiske detaljer
Udgivet i:Trends Immunol
Main Authors: Vanpouille-Box, Claire, Formenti, Silvia
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972064/
https://ncbi.nlm.nih.gov/pubmed/29598848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2018.03.002
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