In Vitro and In Vivo Activities of DS-2969b, a Novel GyrB Inhibitor, and Its Water-Soluble Prodrug, DS11960558, against Methicillin-Resistant Staphylococcus aureus

DS-2969b is a novel GyrB inhibitor under clinical development. In this study, the in vitro activity of DS-2969b and the in vivo activities of DS-2969b and its water-soluble prodrug, DS11960558, against methicillin-resistant Staphylococcus aureus (MRSA) were evaluated. DS-2969b inhibited the supercoi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Barman, Tarani Kanta, Kumar, Manoj, Mathur, Tarun, Namba, Eiko, Singh, Diksha, Chaira, Tridib, Kurosaka, Yuichi, Yamada, Makiko, Upadhyay, Dilip Jatashankar, Masuda, Nobuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971602/
https://ncbi.nlm.nih.gov/pubmed/29610202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02556-17
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