TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates

The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates is redirected via TonB-dependent receptors (TBDR), which are involved in the...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Luscher, Alexandre, Moynié, Lucile, Auguste, Pamela Saint, Bumann, Dirk, Mazza, Lena, Pletzer, Daniel, Naismith, James H., Köhler, Thilo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971595/
https://ncbi.nlm.nih.gov/pubmed/29555629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00097-18
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