Reduced NLRP3 Gene Expression Limits the IL-1β Cleavage via Inflammasome in Monocytes from Severely Injured Trauma Patients

OBJECTIVE: Traumatic injury or severe surgery leads to a profound immune response with a diminished functionality of monocytes and subsequently their IL-1β release. IL-1β plays an important role in host immunity and protection against infections. Its biological activation via IL-1β-precursor process...

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Vydáno v:Mediators Inflamm
Hlavní autoři: Kany, Shinwan, Horstmann, Johann-Philipp, Sturm, Ramona, Mörs, Katharina, Relja, Borna
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971319/
https://ncbi.nlm.nih.gov/pubmed/29861655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1752836
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