טוען...
Determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors through the support of electronic circular dichroism and MM-GBSA techniques
We have previously reported benzimidazole-based compounds to be potent inhibitors of FabI for Francisella tularensis (FtFabI), making them promising antimicrobial hits. Optically active enantiomers exhibit markedly differing affinities toward FtFabI. The IC(50) of benzimidazole (-)-1 is ∼100× lower...
שמור ב:
| הוצא לאור ב: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970947/ https://ncbi.nlm.nih.gov/pubmed/29730028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.04.052 |
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