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Metabolically-derived lysine acylations and neighboring modifications tune BET bromodomain binding to histone H4
Recent proteomic studies discovered histone lysines are modified by acylations beyond acetylation. These acylations derive from acyl-CoA metabolites, potentially linking metabolism to transcription. Bromodomains bind lysine acylation on histones and other nuclear proteins to influence transcription....
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970795/ https://ncbi.nlm.nih.gov/pubmed/28945351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00595 |
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