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Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
BACKGROUND: The simplicity of the CRISPR/Cas9 system has enabled its widespread applications in generating animal models, functional genomic screening and in treating genetic and infectious diseases. However, unintended mutations produced by off-target CRISPR/Cas9 nuclease activity may lead to negat...
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| 出版年: | BMC Genomics |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970491/ https://ncbi.nlm.nih.gov/pubmed/29801435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4712-z |
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