Učitavanje...
Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
BACKGROUND: The simplicity of the CRISPR/Cas9 system has enabled its widespread applications in generating animal models, functional genomic screening and in treating genetic and infectious diseases. However, unintended mutations produced by off-target CRISPR/Cas9 nuclease activity may lead to negat...
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| Izdano u: | BMC Genomics |
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| Glavni autori: | , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970491/ https://ncbi.nlm.nih.gov/pubmed/29801435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4712-z |
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