Complex Hydrogels Composed of Chitosan with Ring-opened Polyvinyl Pyrrolidone as a Gastroretentive Drug Dosage Form to Enhance the Bioavailability of Bisphosphonates

Complex hydrogels formed with chitosan (CS) and ring-opened polyvinyl pyrrolidone (roPVP) as a swellable mucoadhesive gastroretentive drug dosage form (smGRDDF) were prepared and characterized. CS/roPVP hydrogels were produced by blending CS with roPVP obtained by basic treatment of PVP. Effects of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Su, Chia-Yu, Ho, Hsiu-O, Chen, Ying-Chen, Yu, Yu-Ting, Liu, Der-Zen, Chao, Fang-Ching, Sheu, Ming-Thau
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970250/
https://ncbi.nlm.nih.gov/pubmed/29802291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26432-2
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