Testosterone is an endogenous regulator of BAFF and splenic B cell number

Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased sple...

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Publicado no:Nat Commun
Main Authors: Wilhelmson, Anna S., Lantero Rodriguez, Marta, Stubelius, Alexandra, Fogelstrand, Per, Johansson, Inger, Buechler, Matthew B., Lianoglou, Steve, Kapoor, Varun N., Johansson, Maria E., Fagman, Johan B., Duhlin, Amanda, Tripathi, Prabhanshu, Camponeschi, Alessandro, Porse, Bo T., Rolink, Antonius G., Nissbrandt, Hans, Turley, Shannon J., Carlsten, Hans, Mårtensson, Inga-Lill, Karlsson, Mikael C. I., Tivesten, Åsa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970247/
https://ncbi.nlm.nih.gov/pubmed/29802242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04408-0
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