Testosterone is an endogenous regulator of BAFF and splenic B cell number

Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased sple...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Wilhelmson, Anna S., Lantero Rodriguez, Marta, Stubelius, Alexandra, Fogelstrand, Per, Johansson, Inger, Buechler, Matthew B., Lianoglou, Steve, Kapoor, Varun N., Johansson, Maria E., Fagman, Johan B., Duhlin, Amanda, Tripathi, Prabhanshu, Camponeschi, Alessandro, Porse, Bo T., Rolink, Antonius G., Nissbrandt, Hans, Turley, Shannon J., Carlsten, Hans, Mårtensson, Inga-Lill, Karlsson, Mikael C. I., Tivesten, Åsa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970247/
https://ncbi.nlm.nih.gov/pubmed/29802242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04408-0
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