The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms

CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII and replace it with mutated forms in single neurons, we have rigorously addressed its various synaptic roles. In brief...

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Publicat a:Nat Commun
Autors principals: Incontro, Salvatore, Díaz-Alonso, Javier, Iafrati, Jillian, Vieira, Marta, Asensio, Cedric S., Sohal, Vikaas S., Roche, Katherine W., Bender, Kevin J., Nicoll, Roger A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970233/
https://ncbi.nlm.nih.gov/pubmed/29802289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04439-7
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